Asiatic acid inhibits NF-κB signaling and ameliorates experimental acute and chronic colitis in mice.

ABSTRACT:

Objective

This study aimed to elucidate the anti-inflammatory mechanisms of asiatic acid (AA) by focusing on its modulation of the nuclear factor-κB (NF-κB) signaling pathway and to evaluate its therapeutic effects in murine models of both acute and chronic colitis.

Introduction

AA, a naturally occurring triterpenoid compound derived from Centella asiatica, is known for its anti-inflammatory activity. However, its comprehensive effects on both acute and chronic intestinal inflammation, particularly through detailed modulation of the NF-κB pathway, have not been fully elucidated.

Methods

Human intestinal epithelial cells COLO 205 and murine macrophage cells RAW 264.7 were pretreated with AA, followed by stimulation with tumor necrosis factor-α (TNF-α) or lipopol

SUBMITTER: Park S 

PROVIDER: S-EPMC12696327 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature