Metabolic Phenotypes, Genotypes, and Gut Microbiome Signatures in Obesity: Implications for Precision Nutrition Strategies in Type 2 Diabetes Prevention.

ABSTRACT: The worldwide prevalence of overweight and obesity has increased rapidly in the last decades. This rise has led to a surge in comorbidities such as type 2 diabetes (T2D), cardiometabolic diseases, and mental health issues. While general population-based nutrition guidelines have proven effective in reducing T2D incidence by 50%, a significant 30% of participants do not respond to these interventions. Precision nutrition (PN), tailored towards the metabolic phenotype (metabotype), genotype, or microbial characteristics, has shown promise in improving blood glucose control and cardiometabolic health compared with standard nutritional guidelines. This scoping review aims to discuss advancements in PN over the past decade, focusing on heterogeneity in response to dietary interventions aiming t

SUBMITTER: Muijsenberg A 

PROVIDER: S-EPMC12696375 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature