MARVELD1 as a tumor stem cell marker and therapeutic target in visceral obesity-associated ovarian cancer.

ABSTRACT:

Background

Visceral obesity-related genes (VORGs) have been implicated in cancer progression, but their biological and clinical relevance in ovarian cancer (OC) remains uncertain.

Methods

Prognostic modeling of VORGs was carried out using the The Cancer Genome Atlas (TCGA) and GSE53963 datasets. This model was further investigated in its association with tumor immunity, immune checkpoint inhibitor (ICI) response, and chemotherapy outcomes. Additionally, single-cell data were analyzed to explore gene expression within the tumor microenvironment of this model, specifically identifying high expression of the key gene MARVELD1 in tumor stem cells. The functionality of MARVELD1 was validated experimentally through Cell Counting Kit-8 (CCK-8), transwell, and colony formation assay

SUBMITTER: Zhou X 

PROVIDER: S-EPMC12696546 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature