An Imaging-Guided Neural Model Explains Lexical Stress Alteration in Acquired Apraxia of Speech.

ABSTRACT: Acquired apraxia of speech (AOS) is a disorder of speech motor planning/programming that is induced by a lesion to the left anterior ventral precentral sulcus. This study analyses neuroimaging data from AOS in order to propose and computationally test a mechanistic explanation of how the lesion leads to the characteristic of altered lexical stress in the disorder. Neuroimaging data from 31 participants with left hemisphere stroke (15 AOS) were reanalysed to guide a 'lesioned' version of the bilateral GODIVA neuro-computational model of speech production. Structural MRI and resting-state functional MRI measurements were used to decide the model's lesion extent and atypical neural processing, respectively. The 'lesioned' model was compared with a neurotypical model on the production of an ex

SUBMITTER: Civier O 

PROVIDER: S-EPMC12696586 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature