Dataset Information

Risk Factors for West Nile Neuroinvasive Disease and Mortality in the US, 2013-2024.

ABSTRACT:

Importance

West Nile virus (WNV) is the leading mosquito-borne infection in the US, causing West Nile fever or West Nile neuroinvasive disease (WNND) with substantial morbidity and mortality. Contemporary analyses are needed to identify at-risk populations and to target interventions.

Objective

To assess risk factors associated with WNND and mortality among adults with WNV infection using a national cohort from federated data.

Design, setting, and participants

This retrospective cohort study of deidentified electronic medical record data from the TriNetX research network from January 2013 to December 2024 included patients from 65 health care organizations from across the US. Data were accessed from March 28 to April 30, 2025.