Long-Term Postdeployment Clinical Subtypes of Risk and Resiliency in Brain Injury and Neurodegeneration.

ABSTRACT:

Importance

While research has focused on veterans after deployment, fewer studies have examined longitudinal outcomes associated with neurodegeneration. Questions remain about how these trajectories may connect and inform overall risk for later-life neurodegeneration and possible dementia.

Objective

To analyze acute, 1-year, 5-year, and 10-year longitudinal outcomes and magnetic resonance imaging (MRI) data from US military personnel to understand profiles of neurodegenerative resilience and risk.

Design, setting, and participants

This prospective longitudinal, cohort study included data from 4 combat-deployed groups: 2 control groups without head injury (36 individuals with blast exposure and 94 individuals without) and 2 groups with combat-related mild traumatic bra

SUBMITTER: Mac Donald CL 

PROVIDER: S-EPMC12696601 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature