13CFLUX - third-generation high-performance engine for isotopically (non)stationary 13C metabolic flux analysis.

ABSTRACT:

Summary

13C-based metabolic flux analysis is a cornerstone of quantitative systems biology, yet its increasing data complexity and methodological diversity place high demands on simulation software. We introduce 13CFLUX(v3), a third-generation simulation platform that combines a high-performance C++ engine with a convenient Python interface. The software delivers substantial performance gains across isotopically stationary and nonstationary analysis workflows, while remaining flexible to accommodate diverse labeling strategies and analytical platforms. Its open-source availability facilitates seamless integration into computational ecosystems and community-driven extension. By supporting multi-experiment integration, multi-tracer studies, and advanced statistical inference such as

SUBMITTER: Stratmann A 

PROVIDER: S-EPMC12696647 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature