A double-blind replication attempt of offline 5Hz-rTUS-induced corticospinal excitability.

ABSTRACT: Transcranial ultrasound stimulation (TUS) is a promising new form of non-invasive neuromodulation. As a nascent technique, replication of its effects on brain function is important. Of particular interest is offline 5 Hz repetitive TUS (5 Hz-rTUS), originally reported by Zeng et al. (2022) to elicit lasting corticospinal excitability increases, with large effect sizes. Here, we conducted a pre-registered (https://osf.io/p5n4q) replication of this protocol that benefited from three additional features: double-blind application of TUS, neuronavigation for consistent TMS positioning, and individualised 3D acoustic simulations to assess M1 target exposure to TUS. Changes in resting motor thresholds (rMT), motor-evoked potential (MEP) amplitude, short-interval intracortical inhibition (SICI), a

SUBMITTER: Fong PY 

PROVIDER: S-EPMC12696668 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature