Chemotherapeutic Spherical Nucleic Acids.

ABSTRACT: Herein, we describe experiments showing that liposomal spherical nucleic acid (SNA) constructs comprised of 5-fluorouracil (5-Fu) are selectively taken up by myeloid cells, including acute myeloid leukemia (AML) cells, and act as chemotherapeutics. Specifically, SNAs with biocompatible phospholipid-based liposome cores and oligonucleotides consisting of 10 units of the chemically interconnected 5-fluoro-2'-deoxyuridine, were designed and synthesized. These oligonucleotides are modified in the 3' position with hexaethylene glycol and cholesterol end groups, which allow them to be anchored to the liposomal cores. Small-molecule drugs like 5-Fu are conventionally delivered via encapsulation in the liposome interior, but restructuring them in the form of an SNA increases their cellular uptake

SUBMITTER: Luo T 

PROVIDER: S-EPMC12696687 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature