Siglec-E deletion alters AT macrophages phenotypes, induces an inflammatory response, and adipogenesis during diet-induced obesity.

ABSTRACT: Obesity is currently a worldwide health problem, affecting more than 600 million people, and poses a threat to lifestyle and triggers metabolic complications. The infiltration of macrophages into adipose tissue (AT) plays a key role in inducing inflammation and multiple diseases during obesity. Therefore, comprehensive knowledge is required on the crosstalk between adipocytes with resident macrophages in AT to design therapeutic options for obesity and metabolic diseases. While we have demonstrated the role of Siglec-E in inflammation, the mechanism by which Siglec-E induces AT inflammation and adipogenesis remains unclear to date. Thus, this study describes how Siglec-E alters AT macrophages phenotypes, function, and adipogenesis using a high-fat diet (HFD)-induced model of obesity. We sh

SUBMITTER: Rakib A 

PROVIDER: S-EPMC12696692 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature