NLRP3 Inflammasome Activation Modulates Neutrophil Extracellular Trap Formation and Aggravates Airway Inflammation in Bronchiectasis.

ABSTRACT: Neutrophilic inflammation and Pseudomonas aeruginosa infection have been implicated in the pathogenesis and progression of bronchiectasis. However, the mechanisms underlying the inflammasome activation and neutrophil extracellular traps (NETs) formation, which are triggered by lipopolysaccharide (LPS), thereby fostering relentless neutrophilic inflammation and airway destruction, remain poorly understood. Here, we investigated how nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome activation modulates NET formation, epithelial inflammation, and injury in bronchiectasis. Compared with those in the stable state, interleukin-1β levels in the exacerbation state were greater and were correlated with blood neutrophil counts. LPS triggered neutrophil NLR

SUBMITTER: Chen ZM 

PROVIDER: S-EPMC12696696 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature