Gut microbiota metabolites and key target molecules in allergic rhinitis: a multi-omics study of gut-nose axis regulation via the inflammation-metabolism network.

ABSTRACT:

Introduction

Allergic rhinitis (AR) is a globally prevalent immune-mediated disorder. While the "gut-nasal axis" suggests that gut microbiota metabolites can modulate AR, the specific molecular networks and key targets involved remain poorly defined. This study aimed to systematically explore the molecular connections between gut microbiota-derived metabolites and AR, and to identify potential therapeutic targets.

Methods

We performed an integrative multi-omics analysis using databases including gutMGene and GeneCards to identify overlapping genes. Summary-data-based Mendelian randomization (SMR) was used to investigate associations between genetic variation, DNA methylation, gene expression, and AR. Single-cell analysis was conducted to examine gene expression patterns in t

SUBMITTER: Zhang J 

PROVIDER: S-EPMC12696707 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature