Development of a novel patient-oriented tool to assess achalasia symptoms and response to treatment (I-PASS, International Patient-oriented tool for Achalasia Symptom Score).

ABSTRACT: Achalasia treatment outcomes are often assessed using the Eckardt score, which has not been formally validated and is not designed as a patient-reported outcome (PRO) tool. To address this unmet clinical need, a group of healthcare providers developed the International Patient-oriented tool for Achalasia Symptom Score (I-PASS), which aims to record both symptom severity and frequency in a patient-oriented manner. Using the RAND/ University of California, Los Angeles, Appropriateness Methodology, a 16-member international, multidisciplinary panel identified key symptomatic domains through three Delphi rounds. Dysphagia, regurgitation (daytime and nocturnal), and chest pain were selected as primary domains, with weight loss included as an additional factor. Severity and frequency scoring wer

SUBMITTER: Zaninotto G 

PROVIDER: S-EPMC12696712 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature