Total Syntheses of Sappanin-Based Natural Products Enabled by Pattern Recognition Analysis and Brominative Aromatization.

ABSTRACT: Described is a concise route to caesappins A and B, urolithin C, and protosappanin A, which share a common sappanin core. An arylation of a cyclic vinylogous ester and a brominative aromatization were applied to construct a privileged intermediate, which was subsequently converted to the target natural products through strategic coupling reactions.

SUBMITTER: Zhao WT 

PROVIDER: S-EPMC12696778 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature