Machine Learning and Mendelian Randomization Identify Allergic Rhinitis as Nasopharyngeal Carcinoma Risk Factor With Validated Potential Candidate Biomarkers.

ABSTRACT:

Background

Despite extensive research, nasopharyngeal carcinoma (NPC) remains a complex malignancy with poorly understood cellular dynamics and risk factors. The relationship between allergic rhinitis and NPC development has been controversial. This study combined single-cell transcriptomics with Mendelian randomization to comprehensively map cellular heterogeneity and establish potential causal links between allergic rhinitis and NPC pathogenesis.

Methods

Researchers performed single-cell RNA sequencing on NPC and adjacent normal tissue samples. Simultaneously, a two-sample Mendelian randomization approach was employed using allergic rhinitis-associated genetic variants as instrumental variables to investigate causality between allergic rhinitis and NPC risk. Integration of

SUBMITTER: Chen M 

PROVIDER: S-EPMC12696883 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature