MiR499-5P loaded MSC derived exosomes affect oxidative stress and inflammatory response after spinal cord injury by targeting genes.

ABSTRACT: Spinal cord injury (SCI) is a severe and prevalent disorder of the central nervous system that leads to sensory and motor dysfunction, with approximately 700,000 new cases reported annually. Recently, miRNA-mRNA regulatory networks have garnered significant attention from researchers. Preliminary evidence from animal models and bioinformatic analyses suggests that altered miRNA expression affects critical pathophysiological processes in SCI. Therefore, the miRNA-target gene interaction network holds promise as a potential therapeutic avenue to promote neural recovery post-SCI. In this study, we demonstrated for the first time that MSC-EXO-miR499-5P can protect neurons and promote the recovery of motor function in SCI mice. First, we selected the GSE2599 dataset through bioinformatic analys

SUBMITTER: Pang L 

PROVIDER: S-EPMC12696906 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature