Salivary metabolic profile landscape for gastric cancer screening: a metabolomic approach.

ABSTRACT: This study employed non-targeted liquid chromatography-mass spectrometry (LC-MS) to investigate the salivary metabolomic profiles of 177 participants, including 147 patients with gastric cancer (GC) and 30 controls with common gastritis. Following rigorous quality control measures, a total of 333 high-confidence metabolites were identified from an initial pool of 368 positive-mode metabolites and 178 negative-mode metabolites. Principal component analysis (PCA) and linear discriminant analysis (LDA) revealed significant differences between the GC and control groups, with stage I GC clearly distinguishable from more advanced stages. Differential metabolite screening was conducted using partial least squares discriminant analysis (PLS-DA) in conjunction with t-tests and fold-change analysis.

SUBMITTER: Bao C 

PROVIDER: S-EPMC12696939 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature