Repeatable Photoactive Stent-Based Catheter to Enhance Therapeutic Efficacy for Esophageal Carcinoma.

ABSTRACT: Localized photodynamic therapy (PDT) using a photoactive stent-based catheter involves the direct delivery of reactive oxygen species to the mucosa in esophageal carcinoma; however, the damaged mucosa recovers within 2 to 4 weeks, which considerably limits the clinical application of PDT. Here, we used aluminum(III) phthalocyanine chloride tetrasulfonic acid (AlPcS4) as a photosensitizer due to its excellent photochemical durability, low photobleaching, and high quantum yield and investigated whether repeated and periodic PDT via an AlPcS4-embedded stent-based catheter can provide sustained therapeutic efficacy. AlPcS4 was uniformly embedded in silicone membranes via coordination bonding to form a photoactive stent-based catheter. The membrane demonstrated excellent photostability and cons

SUBMITTER: Eo SJ 

PROVIDER: S-EPMC12697060 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature