Manganese-Based Polyoxometalate Nanozyme-Metformin Co-functionalized Hydrogel Promotes Diabetic Wound Regeneration by Enhancing Phagocyte Efferocytosis.

ABSTRACT: Efferocytosis, mediated by macrophages and dendritic cells (DCs), clears apoptotic cells to maintain tissue homeostasis, suppress inflammation, and promote repair. In diabetic wounds, hyperglycemia disrupts their efferocytic function, impeding healing progression. Therefore, restoring the efferocytic capacity of DCs and macrophages and establishing a dynamic "cyclic efferocytosis" between these 2 cell types are critical for diabetic wound regeneration. DCs are key drivers of cyclic efferocytosis because of their tissue-resident properties and glycogenolysis-driven energy supply. We postulated that targeted modulation of DCs was a promising strategy to establish this cycle. We developed GPP-M@L hydrogel, coencapsulating metformin (Met) and DC-targeted MnPOM nanozyme liposomes (Lipo-Dcpep@Mn

SUBMITTER: Li L 

PROVIDER: S-EPMC12697061 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature