Subclinical myocardial dysfunction in pituitary neuroendocrine tumor patients: a 2D speckle-tracking echocardiography study.

ABSTRACT: Pituitary neuroendocrine tumors (PitNETs) cause hormonal hypersecretion, which can disrupt cardiovascular homeostasis and lead to both overt and subclinical cardiac dysfunction. This study retrospectively examined 198 hospitalized PitNET patients (n = 91 male, n = 107 female) from March 2019 to December 2022. Two-dimensional speckle-tracking echocardiography (2D-STE) was used to determine the absolute left ventricular global longitudinal strain (GLS) values. Comprehensive clinical information was gathered, including endocrine axis status, symptoms, surgery history, and demographics. Standard transthoracic echocardiography parameters were also recorded. Multiple linear regression analysis and intergroup comparisons were used to identify factors affecting GLS. Pre-planned subgroup analyses w

SUBMITTER: Li Y 

PROVIDER: S-EPMC12697240 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature