LARIS enables accurate and efficient ligand and receptor interaction analysis in spatial transcriptomics.

ABSTRACT: Advances in spatially resolved transcriptomics provide unprecedented opportunities to characterise intercellular communication pathways. However, robust and computationally efficient incorporation of spatial information into intercellular communication inference remains challenging. Here, we present LARIS (Ligand And Receptor Interaction analysis in Spatial transcriptomics), an accurate and scalable method that identifies cell type-specific and spatially restricted ligand-receptor (LR) interactions at single-cell or bead resolution. LARIS is compatible with all spatial transcriptomic technologies and quantifies specificity, infers sender-receiver directionality, and detects how differential interactions vary across time and space. To compare LARIS with existing methods, we established a si

SUBMITTER: Dai M 

PROVIDER: S-EPMC12697369 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature