Characterization of hippocampal subfields using histology-based annotated postmortem MRI: Lessons for in vivo segmentation II.

ABSTRACT: High-resolution in vivo magnetic resonance imaging (MRI) of hippocampal subfields is a rapidly advancing field due to their implication in cognition, disorder, and disease. Hippocampal subfield segmentation on in vivo MRI is generally guided by postmortem reference material, which has been limited by small sample sizes that preclude comprehensive characterization of subfield border locations and their variability. Addressing this, we characterized hippocampal subfield border variability in two ultra-high-resolution postmortem MRI datasets with combined annotated histological sections, including cases with and without dementia. We examined: 1) the order of appearance and disappearance of subfields along the long axis of the hippocampus; 2) the order of appearance and disappear

SUBMITTER: Tucker HL 

PROVIDER: S-EPMC12697544 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature