MfSuSiE enables multi-cell-type fine-mapping and multi-omic integration of chromatin accessibility QTLs in aging brain.

ABSTRACT: Molecular quantitative trait locus (QTL) studies increasingly profile chromatin accessibility, histone modifications, DNA methylation, RNA modifications such as N6-methyladenosine (m6A), and transcription across multiple cell types using high-throughput sequencing, generating dense base-pair-resolved measurements. The conventional approach of testing each variant against each molecular feature independently suffers from severe multiple testing burden and ignores linkage disequilibrium and spatial correlation. Existing fine-mapping methods only partially address these challenges and are sub-optimal for analyzing such datasets: multivariate approaches such as mvSuSiE jointly analyze multiple molecular contexts but are designed for a single trait value per context and cannot accommodat

SUBMITTER: Liu A 

PROVIDER: S-EPMC12697552 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature