Intra-Arterial Thrombolysis After Mechanical Thrombectomy in Patients with Acute Ischemic Stroke: A Systematic Review and Meta-Analysis With Trial Sequential Analysis.

ABSTRACT:

Background

The potential role of adjunctive intra-arterial thrombolysis (IAT) in improving outcomes following mechanical thrombectomy (MT) remains unclear. This meta-analysis evaluates the efficacy and safety of IAT after MT compared to MT alone in patients with acute ischemic stroke.

Methods

We searched PubMed, Embase, and the Cochrane Library from inception to January 2025 with no language restrictions. Additionally, grey literature sources were explored. Randomized controlled trials comparing IAT after MT versus MT alone in acute ischemic stroke were included. Odds ratios (ORs) with 95% CIs were pooled using a random-effects model in R. Trial sequential analysis was performed for the primary favorable outcomes assuming a 30% relative risk increase, an alpha level of 5%, a

SUBMITTER: Hashmi TM 

PROVIDER: S-EPMC12697616 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature