Antithrombotic Trends Before and After Publication of Randomized Clinical Trials in Cervical Artery Dissection: A Secondary Analysis of the STOP-CAD Study.

ABSTRACT:

Background

Two randomized clinical trials have failed to demonstrate the superiority of anticoagulation over antiplatelet therapy in acute cervical artery dissection, with many patients still receiving anticoagulation despite bleeding risks. In this analysis, we assessed temporal changes in antithrombotic strategies of cervical artery dissection following publication of these 2 trials.

Methods

This is a secondary analysis of a retrospective multinational observational cohort study evaluating outcomes related to antithrombotic treatment for acute cervical artery dissection (January 2015-December 2022). The odds of oral anticoagulant use (over single or combination antiplatelet) therapy across each year were estimated using multivariable logistic regression and joinpoint regre

SUBMITTER: Penckofer M 

PROVIDER: S-EPMC12697651 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature