Liberal Versus Restrictive Transfusion Strategy in Patients With Subarachnoid Hemorrhage: A Meta-Analysis.

ABSTRACT:

Background

The effect of different thresholds for packed red blood cell transfusion on neurologic outcomes in patients with subarachnoid hemorrhage and anemia is uncertain. This meta-analysis aimed to evaluate the effect of liberal versus restrictive transfusion strategies on functional outcomes in subarachnoid hemorrhage.

Methods

We systematically searched MEDLINE (inception-March 26, 2025) for randomized controlled trials comparing functional neurological outcomes in adults with aneurysmal subarachnoid hemorrhage assigned to receive packed red blood cell transfusion using high versus low hemoglobin thresholds. Risk of bias was assessed using Cochrane Risk of Bias tool 2.0. Unfavorable neurologic outcomes were defined based on trial-specific primary neurologic outcome defin

SUBMITTER: Balali P 

PROVIDER: S-EPMC12697660 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature