Metabolic Reprogramming in Retinoblastoma Patients: Treatment Naive Active Retinoblastoma Versus Regressed Tumors Post-Treatment.

ABSTRACT:

Purpose

The purpose of this study was to explore and compare the serum metabolic alterations in treatment-naïve active retinoblastoma (RB) and regressed RB post-treatment.

Methods

Analysis of serum metabolites in six patients with RB before, during, and after completion of treatment and their comparison with six age-matched controls. Serum metabolomics was performed by using 1H nuclear magnetic resonance (NMR) spectroscopy.

Results

Serum metabolomics yielded 70 metabolites, including amino acids, carbohydrates, and organic acids, in patients with RB and healthy controls. Distinct serum metabolite clusters were noted in the PLSDA model for controls, patients with treatment-naïve active RB (AR), and patients with regressed tumors post-treatment (RT). Statistical analysi

SUBMITTER: Gulati K 

PROVIDER: S-EPMC12697687 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature