Exploring the Shared Genetic Architectures Between Primary Open-Angle Glaucoma and Visual Pathway Regions in the Brain.

ABSTRACT:

Purpose

To investigate the genetic relationships between primary open-angle glaucoma (POAG) and major visual pathways in the brain to better understand the neurological biology of glaucoma, which may facilitate the discovery of neuroprotective drug targets.

Methods

We assessed the relationship between POAG and the volumes of five visual pathway regions using genetic correlation and polygenic risk score (PRS). We further used Mendelian randomization (MR) to investigate the causal relationships. In addition, we used genome-wide association study (GWAS)-pairwise analysis to identify genomic segments with shared causal variants and summary data-based MR (SMR) to uncover potential causal genes shared between POAG and the visual brain regions.

Results

We found a weak but si

SUBMITTER: Aman AM 

PROVIDER: S-EPMC12697700 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature