PULSAR: a Foundation Model for Multi-scale and Multi-cellular Biology.

ABSTRACT: Biology emerges from interactions across physical scales, where molecular interactions drive cellular states, which in turn orchestrate multicellular tissue functions that collectively define health and disease. However, current computational models are often constrained to single scales in isolation, failing to integrate the biology that emerges from lower to higher levels [1]. Here we present PULSAR (Patient Understanding Leveraging Single-cell universAl Representation), a multi-scale and multicellular foundation model architecture that explicitly enables information flow from genes to cells to multicellular systems. Applied to the human peripheral immune system, PULSAR extracts a unified donor representation that supports rapid disease classific

SUBMITTER: Pang K 

PROVIDER: S-EPMC12697734 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature