Evaluating the effectiveness of low-dose oral switch therapy for uncomplicated streptococcal or enterococcal bloodstream infection: a retrospective cohort study.

ABSTRACT:

Background

Although oral switch therapy (OST) is increasingly recognized as a viable option for uncomplicated gram-positive bloodstream infections (GP-BSI), its optimal dosage remains unclear. In Japan, high-dose regimens of key oral antimicrobials, such as amoxicillin (1000 mg thrice daily) or levofloxacin (750 mg once daily), are not approved. This study investigated the effectiveness of low-dose OST for GP-BSI in a population with a low prevalence of obesity.

Methods

This retrospective, single-centre study involved patients aged ≥18 years with monomicrobial, uncomplicated BSI caused by ampicillin- or amoxicillin-susceptible Streptococcus or Enterococcus species treated between 2010 and 2023. Patients eligible for OST were identified on day 5 of microbiologic

SUBMITTER: Miwa T 

PROVIDER: S-EPMC12697740 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature