Mechano-Bactericidal Surfaces Achieved by Epitaxial Growth of Metal-Organic Frameworks.

ABSTRACT: Mechano-bactericidal (MB) surfaces have been proposed as an emerging strategy for preventing biofilm formation. Unlike antibiotics and metal ions that chemically interfere with cellular processes, MB nanostructures cause physical damage to the bacteria. The antibacterial performance of artificial MB surfaces relies on rational control of surface features, which is difficult to achieve for large surfaces in real-life applications. Herein, a facile and scalable method is reported for fabricating MB surfaces based on metal-organic frameworks (MOFs) using epitaxial MOF-on-MOF hybrids as building blocks with nanopillars of less than 5 nm tip diameter, 200 nm base diameter, and 300 nm length. Two methods of MOF surface assembly, in situ growth and ex situ dropcasting, result in surfaces with nan

SUBMITTER: Cao Z 

PROVIDER: S-EPMC12697766 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature