Multifunctional Double-Network Hydrogel with Porous, Adhesive, and Immunomodulatory Properties for Minimally Invasive Soft Tissue Repair.

ABSTRACT: The minimally invasive repair of soft tissue defects remains a major clinical challenge due to the lack of biomaterials that simultaneously fulfill key requirements, including extrudability, strong adhesion, seamless integration, bioactivity, and appropriate mechanical properties. Here, a multifunctional double-network composite hydrogel is presented that is synthesized from modified hyaluronic acid (HA) and silk fibroin (SF) through a stepwise gelation process. The incorporation of ferric ions enables dynamic crosslinking of dopamine-grafted HA, resulting in the rapid formation of adhesive hydrogels with microporous structures. Sonication-induced β-sheets in SF form a secondary network, enhancing mechanical strength with reduced swelling and degradation. The inclusion of curcumin-loaded p

SUBMITTER: Nejati S 

PROVIDER: S-EPMC12697792 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature