The Decade of Porcine Circovirus Type 2 (PCV2) in Thailand: Phylodynamic and Molecular Epidemiology.

ABSTRACT: Porcine circovirus type 2 (PCV2) is a major swine pathogen causing significant economic losses in the swine industry worldwide. Continual monitoring of genetic and antigenic diversity is essential for the early detection of emerging variants. This study investigates the evolutionary dynamics and genetic variation of PCV2 circulating in Thailand and across Asia from 2007 to 2024, using integrated phylogenetic and phylodynamic analyses. Analysis of 2739 PCV2 genomes, after excluding 0.99% recombinant strains, revealed four main groups circulating in Asia, with PCV2d as the predominant genotype. PCV2d has diversified into several distinct clades, including a recently identified variant with the ¹³³HDAM¹³⁶ amino acid motif, which likely originated from earlier variants, t

SUBMITTER: Sritrakul T 

PROVIDER: S-EPMC12697814 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature