Adamts1 Exacerbates Post-Myocardial Infarction Scar Formation via Mechanosensing of Integrin α8.

ABSTRACT: -Myocardial infarction (MI) remains a leading cause of morbidity and mortality worldwide, with post-infarction cardiac remodeling, particularly excessive scar formation, representing a critical determinant of patient outcomes. However, the mechanistic pathways governing pathological scar formation remain incompletely understood. Here, we demonstrate that ADAMTS1 (A Disintegrin and Metalloproteinase with Thrombospondin Motifs 1), significantly upregulated in endothelial cells (ECs) following MI, plays a pivotal role in regulating cardiac fibroblast activation through a novel mechanotransduction pathway involving integrin α8 (ITGα8). Using EC-specific ADAMTS1 overexpression and knockout mice combined with cardiac fibroblast-specific ITGα8 deletion models, we found that ADAMTS1 overexpression

SUBMITTER: Kong CY 

PROVIDER: S-EPMC12697874 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature