Luminescent Nanocucurbits Enable Spatiotemporal Co-Delivery of Hydrophilic and Hydrophobic Chemotherapeutic Agents.

ABSTRACT: The generation of nanostructures with asymmetric morphologies has garnered significant attention in nanomedicine research, particularly since morphological characteristics have been shown to critically influence the biological functionality. Herein, the rational design and successful fabrication of luminescent cucurbit-shaped nanoparticles (nanocucurbits) is presented for co-delivery of hydrophilic and hydrophobic chemotherapeutic agents. These innovative nanostructures are obtained through the self-assembly of a tetraphenylethylene (TPE)-graft polypeptide copolymer, poly(ethylene glycol)₄₅-block-poly[(L-glutamic acid-TPE)₂₆-stat-(L-glutamic acid)₂₉] [PEG₄₅-b-P(GATPE₂₆-stat-GA₂₉)], employing an optimized solvent-switch metho

SUBMITTER: Wei P 

PROVIDER: S-EPMC12697897 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature