Comparative Risks of Opioid Overdose in Patients on Oxycodone Initiating Selective Serotonin Reuptake Inhibitors.

ABSTRACT:

Background

Selective serotonin reuptake inhibitors (SSRIs) are often co-prescribed with oxycodone, yet may potentiate respiratory depression. We aimed to assess the comparative effects of SSRIs on opioid overdose when added to oxycodone.

Methods

Using US commercial and public health insurance claims data (2004 - 2020), we conducted a cohort study in adults who initiated SSRI while on oxycodone. We assigned patients to one of five exposures (sertraline, citalopram, escitalopram, fluoxetine, and paroxetine) and followed them for opioid overdose (hospitalization or emergency room visit) for 365 days and while they stayed on both oxycodone and index SSRI. We used propensity score matching weights to adjust for potential confounders and weighted Cox proportional hazard models to

SUBMITTER: Bykov K 

PROVIDER: S-EPMC12697926 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature