IL-17 stimulates erythropoiesis in vivo by amplifying the response of erythroid progenitors to erythropoietin.

ABSTRACT: Red blood cell production is regulated by erythropoietin (Epo), maintaining tissue oxygen tension in the steady state and in response to stress. To date, only a handful of factors other than Epo are known to stimulate erythropoiesis, limiting therapeutic options. We recently found that IL-17, a pleiotropic pro-inflammatory cytokine, interacts synergistically with Epo to increase formation of erythroid colonies in vitro. Here, we administered IL-17 to mice to determine whether it accelerates erythropoiesis in vivo. We found that while IL-17 alone had little effect on erythroid and other hematopoietic lineages, combined treatment with both IL-17 and Epo generated a specific and strong synergistic response in erythroid progenitors that significantly increased erythropoietic rate. IL-17 admini

SUBMITTER: Wu QC 

PROVIDER: S-EPMC12697970 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature