Safety outcomes of statin vs non-statin lipid-lowering interventions in patients with prior statin-associated muscle symptoms: A systematic review and meta-analysis.

ABSTRACT:

Background

Statin-associated muscle symptoms (SAMS) are an obstacle in the prevention of cardiovascular events. A systematic assessment of the evidence of interventions in the setting of SAMS is lacking.

Objective

To assess the evidence of strategies of statin-based vs non-statin based therapies in patients with a history of SAMS.

Methods

MEDLINE, EMBASE, Cochrane Central Register of Controlled Clinical Trials, Scopus, Clinicaltrials.gov and Proquest databases were searched from inception up to February 2024.We included randomized controlled trials (RCTs) and non-randomized studies involving patients with history of prior SAMS, comparing statin-based therapy to a comparator. We followed the PRISMA guideline with multiple authors involved at each stage. A random-effect

SUBMITTER: Aebi PS 

PROVIDER: S-EPMC12698018 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature