A single-cell transcriptomic atlas reveals resident dendritic-like cells in the zebrafish brain parenchyma.

ABSTRACT: Recent studies have highlighted the heterogeneity of the immune cell compartment within the steady-state murine and human CNS. However, it is not known whether this diversity is conserved among non-mammalian vertebrates, especially in the zebrafish, a model system with increasing translational value. Here, we reveal the complexity of the immune landscape of the adult zebrafish brain. Using single-cell transcriptomics, we characterized these different immune cell subpopulations, including cell types that have not been or have only been partially characterized in zebrafish so far. By histology, we found that, despite microglia being the main immune cell type in the parenchyma, the zebrafish brain is also populated by a distinct myeloid population that shares a gene signature with mammalian d

SUBMITTER: Rovira M 

PROVIDER: S-EPMC12698085 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature