The oocyte zinc transporter <i>Slc39a10/Zip10</i> is a regulator of zinc sparks during fertilization in mice.

ABSTRACT: In all vertebrates studied to date, a rise(s) in intracellular calcium is indispensable for successful fertilization and further embryonic development. Recent studies demonstrated that zinc is ejected to the extracellular milieu, the 'zinc spark', and follows the first few calcium rises of fertilization. However, the role of the zinc sparks in fertilization and development, as well as the supporting influx mechanism(s), remains unknown. In this study, we focused on zinc transporters Slc39a10/Zip10 which were expressed in mouse oocytes through follicular development and investigated the oocyte-specific deficient mice for Slc39a10/Zip10 (Slc39a10 cKO: Slc39a10^flox/flox Gdf9^Cre/+). Slc39a10 mRNA or SLC39A10/ZIP10 protein was expressed t

SUBMITTER: Kageyama A 

PROVIDER: S-EPMC12698087 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature