Wide-field cellular-resolution retinal imaging using deformable mirror-based sensorless adaptive optics time-domain full-field OCT.

ABSTRACT: Adaptive optics (AO) enables cellular-resolution retinal imaging by correcting ocular aberrations, but its widespread clinical adoption remains limited by the narrow field of view (FOV) imposed by the isoplanatic patch of the eye. In this study, we present a deformable mirror (DM)-based sensorless AO time-domain full-field OCT (FFOCT) system that overcomes these limitations by leveraging the inherent robustness of FFOCT to ocular aberrations under spatially incoherent illumination. Using both phantom eye simulations and in vivo experiments, we demonstrate that correction of only three to five Zernike modes (defocus, astigmatism, and coma) is sufficient to significantly enhance SNR and resolve fine retinal structures. This includes reliable visualization of cone photoreceptors as close as 0

SUBMITTER: Cai Y 

PROVIDER: S-EPMC12698103 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature