Assessing liquid light guides in diffuse correlation spectroscopy systems.

ABSTRACT: Diffuse correlation spectroscopy (DCS) is a widely used noninvasive optical technique for measuring tissue blood flow. Accurate blood flow estimation with DCS requires a high signal-to-noise ratio (SNR), but achieving high SNR is often limited by safety constraints on the optical irradiance (maximum permissible exposure) that can be delivered to tissue. To overcome this limitation, we investigated the possibility of replacing the conventional multi-mode fiber (MMF) with a liquid light guide (LLG) for illumination. The LLG provides a more uniform illumination profile and higher photon throughput to the tissue under the same irradiance limit, resulting in a significantly increased detected photon count rate and enhanced SNR. In experiments under identical power-density conditions, the LLG-ba

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12698105 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature