Optimizing Patient Selection for Reduced Nonrelapse Mortality After Reduced-Intensity Conditioning: A CIBMTR Analysis.

ABSTRACT:

Background

Reduced-intensity conditioning (RIC) is generally associated with lower nonrelapse mortality (NRM) but higher relapse risk compared to myeloablative conditioning (MAC) in allogeneic hematopoietic cell transplantation (HCT). The Risk assessment for the Intensity of Conditioning regimen in Elderly patients (RICE) score, developed using a large Japanese cohort, was designed to identify patients likely to benefit from reduced NRM with RIC. It is calculated based on three factors: advanced age, high comorbidities, and use of umbilical cord blood donor.

Purpose

In this study, we evaluated the applicability of the RICE score in a Western population using a publicly available CIBMTR dataset.

Study design

This study included 2595 patients aged 40 to 65 years with AM

SUBMITTER: Akahoshi Y 

PROVIDER: S-EPMC12698115 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature