Increased rates of proton pump inhibitor deprescription: a retrospective cohort of patients with upper gastrointestinal bleeding requiring endoscopic intervention.

ABSTRACT:

Objective

Proton pump inhibitors (PPIs) are widely prescribed but inappropriate indications and concerns over long-term side effects have led to recommendations to deprescribe PPIs in certain patients. We previously found a 4-fold increase in PPI deprescription in patients with esophageal strictures. This study aims to assess the PPI deprescription rate in patients with upper gastrointestinal bleeding (UGIB).

Methods

All patients from 2 gastroenterology practices who received endoscopic treatment for UGIB during the years of 2015-2022 were identified using physician billing codes. We defined PPI deprescription as either a 50% dose reduction, frequency reduction, or complete medication discontinuation at the time of endoscopic intervention compared to the established PPI ther

SUBMITTER: Kecskemeti K 

PROVIDER: S-EPMC12698228 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature