Association of Adipose Tissue Insulin Resistance With Risk of Diabetes Incidence in Middle-aged Japanese Workers According to BMI States: 17 Years of Follow-up of the Aichi Worker's Cohort Study.

ABSTRACT:

Background

Insulin resistance in adipocytes, manifested as high basal circulating free fatty acid (FFA) is thought to contribute to the development of type 2 diabetes mellitus (T2DM). However, the association between adipocyte insulin resistance (Adipo-IR) index and T2DM has rarely been explored in prospective studies. We examined this association in a middle-aged Japanese workers' cohort. Since the association may differ according to the degree of overall adiposity, the analysis was stratified by the presence of overweight/obesity defined with body mass index (BMI).

Methods

A total of 3,257 subjects (men 2501, women 756) aged 35-66 years were followed-up for up to 17 years. T2DM incidence was defined as fasting blood glucose level ≥126 mg/dL, glycated hemoglobin level ≥6.5%

SUBMITTER: Akter T 

PROVIDER: S-EPMC12698324 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature