Association between prognostic nutritional index and prognosis in acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation: a retrospective cohort study.

ABSTRACT:

Background

Evidence on the association between prognostic nutritional index (PNI) and prognosis in acute graft-versus-host disease (aGVHD) following allogeneic hematopoietic stem cell transplantation (allo-HSCT) is limited.

Objective

This study aims to investigate the relationship between PNI levels and prognosis in patients experiencing aGVHD following allo-HSCT.

Methods

We conducted a retrospective cohort study of patients who underwent allo-HSCT at Henan Cancer Hospital from January 2019 to December 2024. Eligible patients were those diagnosed with aGVHD following allo-HSCT. Data on PNI levels, clinical outcomes, and demographics were extracted from medical records. The primary outcomes were overall survival (OS) and event-free survival (EFS). Multivariable Cox reg

SUBMITTER: Li G 

PROVIDER: S-EPMC12698373 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature