Unique TCR loci architecture in newts: TRA and TRD separation in <i>Pleurodeles waltl</i>.

ABSTRACT: T cell receptors (TCRs) are central components of the adaptive immune system, yet the genomic organization of TCR-encoding loci is highly complex and has been fully characterized in only a handful of vertebrate taxa. Many important lineages remain largely uncharted, with notable gaps in ectothermic groups. This gap is especially pronounced in amphibians, particularly salamanders (Urodela), where enormous genome sizes have long hindered the availability of high-quality reference sequences. Here, using a recently published chromosome-scale, haplotype-resolved genome of the Iberian ribbed newt, Pleurodeles waltl, we report the first comprehensive characterization of all four TCR loci (TRA, TRB, TRG, and TRD) in this species. P. waltl, alongside the ax

SUBMITTER: Migalska M 

PROVIDER: S-EPMC12698447 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature