Urine Afamin as a biomarker of lupus nephritis.

ABSTRACT:

Objective

The association between various biomarkers and the risk of lupus nephritis (LN) has been extensively investigated. However, a dearth of readily available, specific, and sensitive diagnostic biomarkers for LN remains. This study aimed to examine the levels of Afamin in the urine and plasma of patients with systemic lupus erythematosus (SLE) and to evaluate its potential utility for diagnosing LN.

Methods

This study enrolled 31 LN-SLE patients, 31 non-LN-SLE patients, and 27 healthy controls (HC). First, tandem mass tag (TMT)-based proteomic screening of urine and plasma (n = 15 per group) identified Afamin as a significantly upregulated protein in LN. Subsequently, ELISA validation confirmed that both uAfamin and pAfamin levels were markedly higher in the LN

SUBMITTER: Lin S 

PROVIDER: S-EPMC12698515 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature