Epidemiological characteristics and disease burden of childhood neuroblastoma in Asia: trends and regional differences over the past 30 years.

ABSTRACT:

Background

Neuroblastoma (NB) is the most common extracranial solid tumor in children, with significant clinical heterogeneity. Despite Asia's large pediatric population, comprehensive studies on its disease burden remain limited.

Objective

This study aims to evaluate trends in NB disease burden among Asian children (0-14 years) from 1990 to 2021, examining age, sex, and socioeconomic variations.

Methods

Using Global Burden of Disease (GBD 2021) data, we analyzed incidence, prevalence, deaths, and disability-adjusted life years (DALYs). Statistical analysis was performed using R (v4.5.0), with stratification by Socio-Demographic Index (SDI), age, and sex. Spatial distribution and annual percentage changes were visualized using ggplot2 and heatmaps.

Results

From

SUBMITTER: Li Z 

PROVIDER: S-EPMC12698534 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature