Balanophora polysaccharide improves renal injury and fibrosis in db/db diabetic nephropathy mice via NLRP3 inflammasome mediated inflammation.

ABSTRACT:

Introduction

Diabetic nephropathy (DN) is a major complication of diabetes, with renal fibrosis leading to progressive renal function decline. Understanding interventions for renal injury and fibrosis in DN is vital, and given its complex pathogenesis, new therapeutic agents are urgently needed.

Methods

The DN model was established using db/db mice, which received balanophora polysaccharide (BPS) treatment. The therapeutic efficacy of BPS for DN was evaluated by measuring body weight, fasting blood glucose (FBG), lipid profiles, renal function parameters, serum inflammatory factors, and histopathological changes. Furthermore, the underlying mechanisms by which BPS exerted its therapeutic effects were investigated using transmission electron microscopy (TEM), immunohistochemi

SUBMITTER: Tian C 

PROVIDER: S-EPMC12698541 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature